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Desmoplastic ameloblastoma of Maxilla

Ameloblastoma, a relatively common epithelial odontogenic tumor includes several histopathologic subtypes like follicular, plexiform, acanthomatous and desmoplastic variants. Hybrid desmoplastic ameloblastoma (DA) composed of typical desmoplastic ameloblastoma along with areas of follicular/plexiform ameloblastoma is an extremely rare variant of ameloblastoma.

       Desmoplastic ameloblastoma (DA) was first
described in detail by Eversole et al in 1984 and
is defined as “a variant of ameloblastoma with
specific clinical, imaging and histological                   
features” in the recent WHO classification of
odontogenic tumors. Thus, it often occurs in the
anterior region of jaws, presents with unique
radiographic appearance resembling fibrosseous
lesions and show distinct histopathology
characterized by extensive stromal
collagenisation or desmoplasia surrounding
compressed islands of odontogenic epithelium
making it a distinct entity.



Ameloblastoma is a rare odontogenic tumor accounting for around 1% of all the cysts and tumors in the jaws.It encompasses several histological variants like follicular, plexiform,basaloid,acanthomatous and desmoplastic variants.The striking difference in the anatomic location i.e. occurrence in the anterior-premolar region ofmaxilla/mandible, unusual radiologic presentation of mixed radiolucency-radiopacities with illdefined borders and distinctive histopathology of extensive stromal desmoplasia with scattered odontogenic epithelium makes it a distinct clinicopathologic entity. Additional findings
reported for DA are almost equal sex predilection and relative higher frequency of occurrence in
Asians.







A: Intraoral clinical photograph of the tumor in the
left maxilla. B, PNS view demonstrating a mixed
radiolucent and radiopaque appearance with opacification of
the sinus. Computed tomography scan demonstrating a mixed
radiolucent –radiopaque lesion (C). Cut surface of the gross
specimen demonstrating a solid, granular, creamish white
lesion (D). E: Radiograph of the gross specimen depicting a
mottled appearance with focal radiolucencies.

For further reference :
Source : http://www.easternjmed.org/PDF/2011_1/9.pdf

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